Box 2.2 Definitions
Acute toxicity – adverse effect on an organism after short-term exposure.
Chronic toxicity – adverse long-term effect after long-term exposure (typically at lower concentrations than those causing acute toxicity).
Mixture toxicity – adverse combined effect after exposure to multiple pollutants
Mode of action – understanding of how a chemical acts in an organism or ecosystem
Bioassay – biological test system (organism or cells)
Effect based method (EBM) – bioassay suitable for environmental monitoring
Molecular target - biomolecule (e.g. protein) that directly interacts / binds with a chemical
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Previous comments
POLAND
Mixture toxicity - We would suggest using the same definition of Mixture toxicity as is given in the document "State of the Art Report on Mixture Toxicity" on its page 4 in the first paragraph, in second line (http://ec.europa.eu/environment/chemicals/effects/pdf/report_mixture_toxicity.pdf).
Mode of action - We suggest using the definition alined with term given in the ECHA's document "Mode of Action and Human Relevance Framework in the contents of ...", page 5, first paragraph, first line (https://echa.europa.eu/documents/10162/22816050/moaws_workshop_proceedings_en.pdf/a656803e-4d97-438f-87ff-fc984cfe4836) or with term given in the document "Toxicity and Assessment of Chemical Mixtures EC " page 49, second bullet point, second paragraph (http://ec.europa.eu/health/scientific_committees/environmental_risks/docs/scher_o_155.pdf).
DE-UBA IV 2.2:
This is the definition of chronic toxicity from toxicology, in ecotoxicology there are also chronic tests that are carried out shortly, e.g. the algae test (3 d). Therefore, the definition should be changed: Chronic toxicity – adverse effects on growth, development, reproduction and energy balance.