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It can be difficult to predict the outcome of chemical mixtures on biological effects. In broad terms, the chemicals might a) act independently of each other, exhibiting individual toxicity; b) in combination, be more toxic, as a summed total of the individual chemicals or more toxic than that; c) be less toxic as the chemicals interfere with each other in toxicity mechanisms. For chemicals in a mixture that have the same mode of action, an additive combination effect may be expected (Altenburger et al. 2015, Figure 2.7). Developing knowledge in this way, considering effect contributions from all compounds detected, would be expected to provide stronger association between chemical and ecological assessments.

Figure 2.7 Predicting the outcomes of mixtures - concentration addition for compounds with the same mode of action.

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  • hatfisim (Simon Hatfield) 05 Oct 2018 10:49:58

    page 20 last sentence which states ‘for chemicals in a mixture that have the same mode of action, an additive combination effect may be expected.’   This is inferring a simplistic correlation.  I don’t think this is true - surely the toxicity of the chemicals should be the main factor.  Hence Figure 2.6 is very simplistic and not really giving the whole picture.

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