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For limiting the release of antibiotics themselves in the environment, quality standards for concentrations in water would be relevant both to effluents released during manufacture, and to those from UWWTPs where the substance has been neither metabolised nor degraded during treatment. Reducing the concentrations of antibiotics in the environment from manufacturing relies on good practice to control releases, with a theoretical limit of zero releases. Those arising from medical or veterinary use however, can only be limited to “necessary use”.